Early assessment of dosimetric and biological differences of total marrow irradiation versus total body irradiation in rodents
نویسندگان
چکیده
منابع مشابه
A dosimetric method of total body irradiation.
The determination of the dose delivered to the body during Total Body Irradiation (TBI) is not easy, as direct measurements are impossible. This article presents the intention to develop a systematic and simple method for absorbed dose determination in(60)Co TBI using mid plane dose factors (MDF) and external measurements, i.e. entrance and exit dose readings by semiconductor detectors. In orde...
متن کاملTotal-body irradiation for bone marrow transplantation.
Total-body irradiation (TBI), when given as part of bone marrow transplantation (BMT), works by enhancing immune suppression and by exerting a tumoricidal effect. The modality has been made less toxic because of new approaches to delivering TBI, such as fractionation, and partial organ shielding, Colleen Lawton, MD, professor at the Medical College of Wisconsin, Milwaukee, said at the 1998 Amer...
متن کاملFabrication of anthropomorphic phantoms for use in total body photon irradiation and total skin electron irradiation studies
Introduction: Total Skin Electron Therapy (TSET) and Total Body Irradiation (TBI) are kinds of treatment which use electron and photon beams to treat special types of cancers. The aim of these techniques are to deliver uniform dose to the entire skin while minimizing delivered dose to organs at risk. To check the homogeneity of dose delivery in TBI and TSET, using a humanoid ph...
متن کاملDiode calibration for dose determination in total body irradiation
Background: Total Body Irradiation (TBI) is different from standard radiotherapy in many aspects, so it is not easy to predict the delivered dose to the patient under TBI treatment. Diode dosimetry procedures for surface dose reading can help to define variations of the actually delivered dose from the prescribed one. The aim of this study was to describe the measurements made to calib...
متن کاملEstablishment of Early Endpoints in Mouse Total-Body Irradiation Model
Acute radiation sickness (ARS) following exposure to ionizing irradiation is characterized by radiation-induced multiorgan dysfunction/failure that refers to progressive dysfunction of two or more organ systems, the etiological agent being radiation damage to cells and tissues over time. Radiation sensitivity data on humans and animals has made it possible to describe the signs associated with ...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2017
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2017.07.018